Neurothreads: Development of supportive carriers for mature dopaminergic neuron differentiation and implantation

In this study we present the use of elastic macroporous cryogels for differentiation and transplantation mature neurons. We develop a coating suitable long-term neuronal culture, including stem cell differentiation, by covalent immobilization neural adhesion proteins. context therapy Parkinson's disease, show compatibility with established dopaminergic both immortalized mesencephalic progenitors - LUHMES human embryonic cells (hESCs). adjust structural properties biomaterial to create carriers Neurothreads favourable viability during transplantation. Finally, feasibility preservation neurons, supported Neurothreads, one month after in-vivo Preliminary data suggests that Neurothread approach could provide more less proliferative in vivo.